Drug interactions
Entrectinib + Umeclidinium-vilanterol
Severity: Moderate
Entrectinib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval, and vilanterol may add to the risk of arrhythmia through beta-adrenergic effects and lower potassium. The clinical significance is likely modest with inhaled dosing but matters in patients with other risk factors.
What this interaction means in plain words
Entrectinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and beta-adrenergic cardiac stimulation.
What to do
Monitor ECG and electrolytes, particularly in patients with heart disease or other QT-prolonging drugs. Reduce or interrupt entrectinib according to labeling if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Entrectinib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval, and vilanterol may add to the risk of arrhythmia through beta-adrenergic effects and lower potassium. The clinical significance is likely modest with inhaled dosing but matters in patients with other risk factors.
How serious is the interaction between Entrectinib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, particularly in patients with heart disease or other QT-prolonging drugs. Reduce or interrupt entrectinib according to labeling if the QTc becomes prolonged.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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