Drug interactions
Entrectinib + Vardenafil
Severity: Moderate
Entrectinib and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib can prolong the QT interval and vardenafil has a small additional effect. Together they may increase the risk of torsades de pointes. Entrectinib is also a moderate CYP3A4 inhibitor, which can increase vardenafil exposure.
What this interaction means in plain words
Entrectinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entrectinib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition by entrectinib raising vardenafil levels.
What to do
Monitor the ECG and electrolytes, and use a reduced vardenafil dose. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Entrectinib
Frequently asked questions
Can I take Entrectinib with Vardenafil?
MediHelp rates the interaction as moderate. Entrectinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib can prolong the QT interval and vardenafil has a small additional effect. Together they may increase the risk of torsades de pointes. Entrectinib is also a moderate CYP3A4 inhibitor, which can increase vardenafil exposure.
How serious is the interaction between Entrectinib and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, and use a reduced vardenafil dose. Avoid the combination in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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