Drug interactions
Ephedrine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Ephedrine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine can shift potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss, so hypokalemia may be additive. Ephedrine's pressor effect also opposes the antihypertensive action of the combination.
What this interaction means in plain words
Ephedrine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive potassium lowering (beta-adrenergic cellular uptake plus thiazide kaliuresis) and pharmacodynamic antagonism of blood pressure control by sympathomimetic action.
What to do
Monitor blood pressure and serum potassium when ephedrine is used repeatedly or at high doses. Replace potassium if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Ephedrine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine can shift potassium into cells through beta-2 stimulation, and hydrochlorothiazide causes renal potassium loss, so hypokalemia may be additive. Ephedrine's pressor effect also opposes the antihypertensive action of the combination.
How serious is the interaction between Ephedrine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium when ephedrine is used repeatedly or at high doses. Replace potassium if hypokalemia develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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