Drug interactions
Ephedrine + Levosalbutamol
Severity: Moderate
Ephedrine and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic with direct and indirect adrenergic activity, and combining it with levosalbutamol produces additive cardiovascular stimulation. This can cause tachycardia, palpitations, hypertension and tremor, and may modestly lower potassium.
What this interaction means in plain words
Ephedrine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Additive adrenergic receptor stimulation, with beta-2 mediated potassium shift.
What to do
Monitor blood pressure, heart rate and symptoms of excess sympathomimetic activity. Avoid concurrent use in patients with significant cardiovascular disease or arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Levosalbutamol?
MediHelp rates the interaction as moderate. Ephedrine and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine is a sympathomimetic with direct and indirect adrenergic activity, and combining it with levosalbutamol produces additive cardiovascular stimulation. This can cause tachycardia, palpitations, hypertension and tremor, and may modestly lower potassium.
How serious is the interaction between Ephedrine and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and symptoms of excess sympathomimetic activity. Avoid concurrent use in patients with significant cardiovascular disease or arrhythmias.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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