Drug interactions
Epinephrine + Ethinyl estradiol-drospirenone
Severity: Minor
Epinephrine and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise potassium, whereas epinephrine shifts potassium into cells through beta-2 stimulation and transiently lowers serum levels. The effects oppose each other and are of little practical significance.
What this interaction means in plain words
Epinephrine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Opposing effects on potassium: aldosterone antagonism by drospirenone versus beta-2-mediated cellular potassium uptake from epinephrine.
What to do
No action is usually needed for emergency or occasional epinephrine use. Check serum potassium if epinephrine is used repeatedly or in a patient with renal disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Epinephrine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone can raise potassium, whereas epinephrine shifts potassium into cells through beta-2 stimulation and transiently lowers serum levels. The effects oppose each other and are of little practical significance.
How serious is the interaction between Epinephrine and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed for emergency or occasional epinephrine use. Check serum potassium if epinephrine is used repeatedly or in a patient with renal disease.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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