Drug interactions
Epinephrine + Fluphenazine
Severity: Moderate
Epinephrine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-blocking activity, so epinephrine may cause unopposed beta-mediated vasodilation and hypotension. Both can also contribute to arrhythmias.
What this interaction means in plain words
Epinephrine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Fluphenazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by fluphenazine reverses epinephrine pressor effect, with additive proarrhythmic effects.
What to do
Use epinephrine when needed for anaphylaxis but monitor blood pressure and ECG. Use norepinephrine or phenylephrine if a pressor is required for hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Epinephrine and Fluphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Fluphenazine?
MediHelp rates the interaction as moderate. Epinephrine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has alpha-blocking activity, so epinephrine may cause unopposed beta-mediated vasodilation and hypotension. Both can also contribute to arrhythmias.
How serious is the interaction between Epinephrine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine when needed for anaphylaxis but monitor blood pressure and ECG. Use norepinephrine or phenylephrine if a pressor is required for hypotension.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
