Drug interactions
Epinephrine + Fluvoxamine
Severity: Minor
Epinephrine and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can cause tachycardia, arrhythmias and QT prolongation, and fluvoxamine has a small QT effect, so the combination may add to arrhythmia risk. The relevance is greatest with systemic or repeated high-dose epinephrine, and less so with a single emergency dose.
What this interaction means in plain words
Epinephrine and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive proarrhythmic and QT-prolonging effects, which are mostly pharmacodynamic.
What to do
Use usual epinephrine doses when it is needed for emergencies such as anaphylaxis. With infusions or in patients with heart disease, monitor ECG and electrolytes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Fluvoxamine?
MediHelp rates the interaction as minor. Epinephrine and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine can cause tachycardia, arrhythmias and QT prolongation, and fluvoxamine has a small QT effect, so the combination may add to arrhythmia risk. The relevance is greatest with systemic or repeated high-dose epinephrine, and less so with a single emergency dose.
How serious is the interaction between Epinephrine and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use usual epinephrine doses when it is needed for emergencies such as anaphylaxis. With infusions or in patients with heart disease, monitor ECG and electrolytes.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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