Drug interactions
Epinephrine + Haloperidol
Severity: Moderate
Epinephrine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol has some alpha-blocking activity, so epinephrine may cause unopposed beta-mediated vasodilation and hypotension. Both drugs may also contribute to arrhythmia. Concern is greatest with systemic doses.
What this interaction means in plain words
Epinephrine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Haloperidol belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by haloperidol alters the pressor response to epinephrine, with possible additive arrhythmic effects.
What to do
Monitor blood pressure and ECG when systemic epinephrine is used. Use norepinephrine or phenylephrine for hypotension that persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Haloperidol?
MediHelp rates the interaction as moderate. Epinephrine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol has some alpha-blocking activity, so epinephrine may cause unopposed beta-mediated vasodilation and hypotension. Both drugs may also contribute to arrhythmia. Concern is greatest with systemic doses.
How serious is the interaction between Epinephrine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG when systemic epinephrine is used. Use norepinephrine or phenylephrine for hypotension that persists.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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