Drug interactions
Epinephrine + Iloperidone
Severity: Major
Epinephrine and Iloperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval, and epinephrine can provoke tachycardia, hypokalemia and arrhythmias. Together they may raise the risk of torsades de pointes, and iloperidone's alpha-blockade may also cause a paradoxical hypotensive response to epinephrine.
What this interaction means in plain words
Epinephrine and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epinephrine belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT effects with beta-mediated hypokalemia, plus alpha-1 antagonism by iloperidone opposing epinephrine's vasoconstriction.
What to do
Monitor ECG, potassium and magnesium, and blood pressure when both are needed. Correct electrolyte abnormalities and use vasopressors other than epinephrine for hypotension in patients on iloperidone where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Epinephrine with Iloperidone?
MediHelp rates the interaction as major. Epinephrine and Iloperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone prolongs the QT interval, and epinephrine can provoke tachycardia, hypokalemia and arrhythmias. Together they may raise the risk of torsades de pointes, and iloperidone's alpha-blockade may also cause a paradoxical hypotensive response to epinephrine.
How serious is the interaction between Epinephrine and Iloperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and blood pressure when both are needed. Correct electrolyte abnormalities and use vasopressors other than epinephrine for hypotension in patients on iloperidone where possible.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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