Drug interactions
Epinephrine + Indacaterol-glycopyrronium
Severity: Moderate
Epinephrine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is a potent adrenergic agonist, and indacaterol is a long-acting beta2-agonist. Together they may potentiate tachycardia, arrhythmias, hypertension, tremor and hypokalemia. Epinephrine for anaphylaxis should not be withheld, but cardiovascular effects may be amplified.
What this interaction means in plain words
Epinephrine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor stimulation.
What to do
Use epinephrine when clinically indicated, with cardiac monitoring and potassium checks where feasible. Avoid unnecessary additional sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Epinephrine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine is a potent adrenergic agonist, and indacaterol is a long-acting beta2-agonist. Together they may potentiate tachycardia, arrhythmias, hypertension, tremor and hypokalemia. Epinephrine for anaphylaxis should not be withheld, but cardiovascular effects may be amplified.
How serious is the interaction between Epinephrine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine when clinically indicated, with cardiac monitoring and potassium checks where feasible. Avoid unnecessary additional sympathomimetics.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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