Drug interactions
Epinephrine + Levomilnacipran
Severity: Moderate
Epinephrine and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran inhibits norepinephrine reuptake and can enhance the pressor and chronotropic effects of epinephrine. This may cause hypertension, tachycardia or arrhythmias.
What this interaction means in plain words
Epinephrine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Levomilnacipran belongs to Central Nervous System.
Why it happens
Inhibition of norepinephrine reuptake potentiates adrenergic effects.
What to do
Monitor blood pressure and heart rate and use the lowest effective epinephrine dose. Be cautious with vasoconstrictor-containing local anesthetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Epinephrine with Levomilnacipran?
MediHelp rates the interaction as moderate. Epinephrine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran inhibits norepinephrine reuptake and can enhance the pressor and chronotropic effects of epinephrine. This may cause hypertension, tachycardia or arrhythmias.
How serious is the interaction between Epinephrine and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and use the lowest effective epinephrine dose. Be cautious with vasoconstrictor-containing local anesthetics.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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