Drug interactions
Epinephrine + Midazolam
Severity: Minor
Epinephrine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine has no meaningful interaction with midazolam metabolism, and any effect on alertness is incidental to its hemodynamic action. No consistent or clinically important interaction is established.
What this interaction means in plain words
Epinephrine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Epinephrine belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism; opposing physiologic effects of adrenergic stimulation and benzodiazepine sedation.
What to do
No specific action is needed beyond routine monitoring of sedation and hemodynamics.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Midazolam?
MediHelp rates the interaction as minor. Epinephrine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epinephrine has no meaningful interaction with midazolam metabolism, and any effect on alertness is incidental to its hemodynamic action. No consistent or clinically important interaction is established.
How serious is the interaction between Epinephrine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of sedation and hemodynamics.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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