Drug interactions
Epinephrine + Moxifloxacin
Severity: Moderate
Epinephrine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can prolong the QT interval and provoke arrhythmias through adrenergic stimulation, and moxifloxacin adds to repolarization risk. The concern is greatest with systemic doses and less so with small local anesthetic doses or emergency use.
What this interaction means in plain words
Epinephrine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Adrenergic stimulation and hypokalemic effects combined with moxifloxacin IKr blockade increase arrhythmia susceptibility.
What to do
Do not withhold epinephrine in anaphylaxis or cardiac arrest. For nonurgent systemic use, monitor ECG and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Moxifloxacin?
MediHelp rates the interaction as moderate. Epinephrine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can prolong the QT interval and provoke arrhythmias through adrenergic stimulation, and moxifloxacin adds to repolarization risk. The concern is greatest with systemic doses and less so with small local anesthetic doses or emergency use.
How serious is the interaction between Epinephrine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold epinephrine in anaphylaxis or cardiac arrest. For nonurgent systemic use, monitor ECG and potassium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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