Drug interactions
Epinephrine + Nabilone
Severity: Moderate
Epinephrine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine is a sympathomimetic that raises heart rate and blood pressure, and nabilone can cause tachycardia, so combined use may increase cardiovascular stimulation. Any effect on sedation is uncertain and should not be relied on.
What this interaction means in plain words
Epinephrine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive tachycardic and cardiovascular effects; the CNS interaction is not established.
What to do
Monitor heart rate and blood pressure when epinephrine is given to patients taking nabilone. Do not withhold epinephrine in emergencies such as anaphylaxis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Nabilone?
MediHelp rates the interaction as moderate. Epinephrine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine is a sympathomimetic that raises heart rate and blood pressure, and nabilone can cause tachycardia, so combined use may increase cardiovascular stimulation. Any effect on sedation is uncertain and should not be relied on.
How serious is the interaction between Epinephrine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when epinephrine is given to patients taking nabilone. Do not withhold epinephrine in emergencies such as anaphylaxis.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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