Drug interactions
Epinephrine + Perphenazine
Severity: Moderate
Epinephrine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has alpha-adrenergic blocking activity, so epinephrine can produce unopposed beta-mediated vasodilation and hypotension. Both agents may also affect cardiac rhythm and QT. This is mostly relevant with systemic doses, for example during anaphylaxis treatment.
What this interaction means in plain words
Epinephrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Alpha-adrenergic blockade by perphenazine reverses the pressor effect of epinephrine, with possible additive arrhythmogenic effects.
What to do
Monitor blood pressure and ECG when systemic epinephrine is given to patients taking perphenazine. Use epinephrine as needed in emergencies and use a pure vasopressor such as norepinephrine for refractory hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Perphenazine?
MediHelp rates the interaction as moderate. Epinephrine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has alpha-adrenergic blocking activity, so epinephrine can produce unopposed beta-mediated vasodilation and hypotension. Both agents may also affect cardiac rhythm and QT. This is mostly relevant with systemic doses, for example during anaphylaxis treatment.
How serious is the interaction between Epinephrine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG when systemic epinephrine is given to patients taking perphenazine. Use epinephrine as needed in emergencies and use a pure vasopressor such as norepinephrine for refractory hypotension.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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