Drug interactions
Epinephrine + Phentermine
Severity: Moderate
Epinephrine and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic amine that promotes norepinephrine release, and epinephrine adds direct adrenergic stimulation. Together they may cause additive increases in blood pressure and heart rate and raise the risk of arrhythmia.
What this interaction means in plain words
Epinephrine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Phentermine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects from indirect catecholamine release and direct adrenergic agonism.
What to do
Monitor blood pressure, heart rate and rhythm when epinephrine is given to patients taking phentermine. Use the lowest effective epinephrine dose, including in local anesthetic preparations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Epinephrine with Phentermine?
MediHelp rates the interaction as moderate. Epinephrine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic amine that promotes norepinephrine release, and epinephrine adds direct adrenergic stimulation. Together they may cause additive increases in blood pressure and heart rate and raise the risk of arrhythmia.
How serious is the interaction between Epinephrine and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm when epinephrine is given to patients taking phentermine. Use the lowest effective epinephrine dose, including in local anesthetic preparations.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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