Drug interactions
Epinephrine + Voriconazole
Severity: Moderate
Epinephrine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can cause hypokalemia and arrhythmias and has been listed as QT-affecting, so combined use with voriconazole may add to arrhythmic risk. For emergency use such as anaphylaxis or cardiac arrest, the benefit clearly outweighs this concern.
What this interaction means in plain words
Epinephrine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epinephrine belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Additive proarrhythmic effects: beta-adrenergic hypokalemia and QT effects combined with voriconazole QT prolongation.
What to do
Use epinephrine when indicated without delay; monitor ECG and potassium in non-emergency or repeated use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Epinephrine with Voriconazole?
MediHelp rates the interaction as moderate. Epinephrine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can cause hypokalemia and arrhythmias and has been listed as QT-affecting, so combined use with voriconazole may add to arrhythmic risk. For emergency use such as anaphylaxis or cardiac arrest, the benefit clearly outweighs this concern.
How serious is the interaction between Epinephrine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine when indicated without delay; monitor ECG and potassium in non-emergency or repeated use.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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