Drug interactions
Epinephrine racemic + Fluphenazine
Severity: Minor
Epinephrine racemic and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines block alpha-adrenergic receptors, so epinephrine's vasoconstriction can be reversed, leaving beta effects unopposed and causing hypotension and tachycardia. Racemic epinephrine, usually given by inhalation for airway swelling, has limited systemic exposure, and the QT concern is minor.
What this interaction means in plain words
Epinephrine racemic and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Alpha-adrenergic blockade by fluphenazine opposes epinephrine pressor effects; additive QT effects are theoretical.
What to do
Monitor blood pressure and heart rate when epinephrine is used systemically; no change is usually required for inhaled racemic epinephrine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Epinephrine racemic with Fluphenazine?
MediHelp rates the interaction as minor. Epinephrine racemic and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines block alpha-adrenergic receptors, so epinephrine's vasoconstriction can be reversed, leaving beta effects unopposed and causing hypotension and tachycardia. Racemic epinephrine, usually given by inhalation for airway swelling, has limited systemic exposure, and the QT concern is minor.
How serious is the interaction between Epinephrine racemic and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when epinephrine is used systemically; no change is usually required for inhaled racemic epinephrine.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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