Drug interactions
Epinephrine racemic + Haloperidol
Severity: Moderate
Epinephrine racemic and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine, mainly when systemically absorbed, can provoke arrhythmias and may prolong QT, which adds to haloperidol's effect. Haloperidol may also blunt the pressor response to adrenergic agents through alpha-blockade. Inhaled use for airway edema has limited systemic exposure.
What this interaction means in plain words
Epinephrine racemic and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic arrhythmogenic effects combined with haloperidol QT prolongation and alpha-adrenergic antagonism.
What to do
Monitor heart rate, blood pressure and ECG when systemic exposure is expected. Correct electrolytes and avoid repeated dosing in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Haloperidol?
MediHelp rates the interaction as moderate. Epinephrine racemic and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine, mainly when systemically absorbed, can provoke arrhythmias and may prolong QT, which adds to haloperidol's effect. Haloperidol may also blunt the pressor response to adrenergic agents through alpha-blockade. Inhaled use for airway edema has limited systemic exposure.
How serious is the interaction between Epinephrine racemic and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when systemic exposure is expected. Correct electrolytes and avoid repeated dosing in patients with other QT risk factors.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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