Drug interactions
Epinephrine racemic + Hydrochlorothiazide-lisinopril
Severity: Moderate
Epinephrine racemic and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine stimulates beta-2 receptors, which can lower serum potassium transiently. Together with thiazide-induced potassium loss, this may increase the risk of hypokalemia and arrhythmia, particularly with repeated or high-dose use.
What this interaction means in plain words
Epinephrine racemic and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonism shifts potassium into cells, adding to renal potassium loss from thiazide.
What to do
Check serum potassium in patients receiving frequent dosing or with cardiac disease, and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Epinephrine racemic with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Epinephrine racemic and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine stimulates beta-2 receptors, which can lower serum potassium transiently. Together with thiazide-induced potassium loss, this may increase the risk of hypokalemia and arrhythmia, particularly with repeated or high-dose use.
How serious is the interaction between Epinephrine racemic and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients receiving frequent dosing or with cardiac disease, and correct hypokalemia.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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