Drug interactions
Epinephrine racemic + Moxifloxacin
Severity: Moderate
Epinephrine racemic and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine is a sympathomimetic that can provoke tachyarrhythmias and may add to QT-related risk with moxifloxacin. Clinical significance depends on route and dose, since inhaled use gives low systemic exposure.
What this interaction means in plain words
Epinephrine racemic and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Adrenergic stimulation and hypokalemia may add to the QT-prolonging effect of moxifloxacin; the effect is mainly pharmacodynamic.
What to do
Monitor heart rhythm and potassium in patients with cardiac risk factors receiving systemic or repeated doses. Avoid in patients with known QT prolongation or uncorrected electrolyte disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Epinephrine racemic with Moxifloxacin?
MediHelp rates the interaction as moderate. Epinephrine racemic and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine is a sympathomimetic that can provoke tachyarrhythmias and may add to QT-related risk with moxifloxacin. Clinical significance depends on route and dose, since inhaled use gives low systemic exposure.
How serious is the interaction between Epinephrine racemic and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and potassium in patients with cardiac risk factors receiving systemic or repeated doses. Avoid in patients with known QT prolongation or uncorrected electrolyte disorders.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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