Drug interactions
Eplerenone + Lumefantrine
Severity: Minor
Eplerenone and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a substrate of CYP3A4 and its interaction with eplerenone is poorly characterized. A pharmacokinetic change is unlikely to be clinically relevant over a short antimalarial course.
What this interaction means in plain words
Eplerenone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 effect that is not well established.
What to do
No specific action is required for a short course. Monitor blood pressure and serum potassium if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Lumefantrine?
MediHelp rates the interaction as minor. Eplerenone and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine is a substrate of CYP3A4 and its interaction with eplerenone is poorly characterized. A pharmacokinetic change is unlikely to be clinically relevant over a short antimalarial course.
How serious is the interaction between Eplerenone and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required for a short course. Monitor blood pressure and serum potassium if clinically indicated.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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