Drug interactions
Eplerenone + Miconazole vaginal
Severity: Minor
Eplerenone and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor and systemic absorption from vaginal use is low but not zero. A clinically significant rise in eplerenone exposure is unlikely with short topical courses.
What this interaction means in plain words
Eplerenone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Limited CYP3A4 inhibition by absorbed miconazole.
What to do
No routine action is required for a short vaginal course. Monitor serum potassium if prolonged or high-dose use occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Miconazole vaginal?
MediHelp rates the interaction as minor. Eplerenone and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP3A4 inhibitor and systemic absorption from vaginal use is low but not zero. A clinically significant rise in eplerenone exposure is unlikely with short topical courses.
How serious is the interaction between Eplerenone and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required for a short vaginal course. Monitor serum potassium if prolonged or high-dose use occurs.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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