Drug interactions
Eplerenone + Nitroglycerin rectal
Severity: Minor
Eplerenone and Nitroglycerin rectal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, so using them together may produce additive hypotension. Rectal nitroglycerin has some systemic absorption, so dizziness or fainting may occur, especially when treatment is started or doses are raised.
What this interaction means in plain words
Eplerenone and Nitroglycerin rectal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering from nitrate vasodilation and the mild antihypertensive effect of aldosterone antagonism.
What to do
Check blood pressure and ask about orthostatic symptoms when starting or changing either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Nitroglycerin rectal?
MediHelp rates the interaction as minor. Eplerenone and Nitroglycerin rectal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can lower blood pressure, so using them together may produce additive hypotension. Rectal nitroglycerin has some systemic absorption, so dizziness or fainting may occur, especially when treatment is started or doses are raised.
How serious is the interaction between Eplerenone and Nitroglycerin rectal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and ask about orthostatic symptoms when starting or changing either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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