Drug interactions
Eplerenone + Olanzapine / samidorphan
Severity: Minor
Eplerenone and Olanzapine / samidorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering effect of eplerenone. Patients may experience dizziness or falls.
What this interaction means in plain words
Eplerenone and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effects through alpha-adrenergic blockade (olanzapine) and diuretic/antihypertensive action (eplerenone).
What to do
Monitor blood pressure, especially orthostatic changes, and lower the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Olanzapine / samidorphan?
MediHelp rates the interaction as minor. Eplerenone and Olanzapine / samidorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Olanzapine can cause orthostatic hypotension, which may add to the blood pressure lowering effect of eplerenone. Patients may experience dizziness or falls.
How serious is the interaction between Eplerenone and Olanzapine / samidorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially orthostatic changes, and lower the antihypertensive dose if hypotension develops.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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