Drug interactions
Eplerenone + Parecoxib
Severity: Moderate
Eplerenone and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to the COX-2 inhibitor valdecoxib and can reduce the antihypertensive effect of eplerenone. It can also impair renal function and raise the risk of hyperkalemia.
What this interaction means in plain words
Eplerenone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, causing sodium retention and reduced potassium excretion.
What to do
Monitor blood pressure, serum potassium and creatinine during co-therapy. Keep the parecoxib course short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Parecoxib?
MediHelp rates the interaction as moderate. Eplerenone and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is converted to the COX-2 inhibitor valdecoxib and can reduce the antihypertensive effect of eplerenone. It can also impair renal function and raise the risk of hyperkalemia.
How serious is the interaction between Eplerenone and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine during co-therapy. Keep the parecoxib course short.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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