Drug interactions
Eplerenone + Pentobarbital
Severity: Moderate
Eplerenone and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower eplerenone concentrations. This could reduce the blood pressure or heart failure benefit of eplerenone.
What this interaction means in plain words
Eplerenone and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of hepatic and intestinal CYP3A4 increases eplerenone metabolism.
What to do
Monitor blood pressure and clinical response to eplerenone, and consider a dose increase if efficacy is lost. Recheck serum potassium after any dose change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Pentobarbital?
MediHelp rates the interaction as moderate. Eplerenone and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may lower eplerenone concentrations. This could reduce the blood pressure or heart failure benefit of eplerenone.
How serious is the interaction between Eplerenone and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response to eplerenone, and consider a dose increase if efficacy is lost. Recheck serum potassium after any dose change.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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