Drug interactions
Eplerenone + Phenobarbital
Severity: Moderate
Eplerenone and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a CYP3A4 inducer and may reduce eplerenone exposure. Reduced efficacy in hypertension or heart failure may result.
What this interaction means in plain words
Eplerenone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induces hepatic and intestinal CYP3A4, increasing eplerenone clearance.
What to do
Monitor blood pressure and clinical response, and adjust the eplerenone dose if needed. Check potassium after dose changes or when phenobarbital is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Phenobarbital?
MediHelp rates the interaction as moderate. Eplerenone and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a CYP3A4 inducer and may reduce eplerenone exposure. Reduced efficacy in hypertension or heart failure may result.
How serious is the interaction between Eplerenone and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response, and adjust the eplerenone dose if needed. Check potassium after dose changes or when phenobarbital is started or stopped.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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