Drug interactions
Eplerenone + Potassium chloride
Severity: Contraindicated
Eplerenone and Potassium chloride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eplerenone limits renal potassium loss, and potassium chloride supplies additional potassium. The combination can cause severe, life-threatening hyperkalemia.
What this interaction means in plain words
Eplerenone and Potassium chloride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eplerenone belongs to Cardiovascular; Potassium chloride belongs to Gastrointestinal Tract.
Why it happens
Additive potassium retention from aldosterone antagonism plus exogenous potassium intake.
What to do
Do not use potassium supplements with eplerenone in labeled hypertension use; otherwise avoid and monitor potassium closely if clinically unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Potassium chloride
Frequently asked questions
Can I take Eplerenone with Potassium chloride?
MediHelp rates the interaction as contraindicated. Eplerenone and Potassium chloride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eplerenone limits renal potassium loss, and potassium chloride supplies additional potassium. The combination can cause severe, life-threatening hyperkalemia.
How serious is the interaction between Eplerenone and Potassium chloride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use potassium supplements with eplerenone in labeled hypertension use; otherwise avoid and monitor potassium closely if clinically unavoidable.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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