Drug interactions
Eplerenone + Salicylates
Severity: Minor
Eplerenone and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates may blunt the antihypertensive effect of eplerenone and can worsen renal function and potassium handling. The effect is probably less than with other NSAIDs.
What this interaction means in plain words
Eplerenone and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of renal prostaglandin synthesis reduces natriuresis and renal perfusion.
What to do
Monitor blood pressure, renal function and potassium if used regularly or at high doses. Prefer the lowest effective salicylate dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Salicylates?
MediHelp rates the interaction as minor. Eplerenone and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates may blunt the antihypertensive effect of eplerenone and can worsen renal function and potassium handling. The effect is probably less than with other NSAIDs.
How serious is the interaction between Eplerenone and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if used regularly or at high doses. Prefer the lowest effective salicylate dose.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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