Drug interactions
Eplerenone + Salsalate
Severity: Moderate
Eplerenone and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate may reduce the blood pressure lowering effect of eplerenone and may impair renal function. In patients with reduced kidney function it can add to the risk of hyperkalemia.
What this interaction means in plain words
Eplerenone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces sodium excretion and renal blood flow.
What to do
Monitor blood pressure, serum creatinine and potassium, especially in older patients or those with CKD. Use the lowest effective salsalate dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Salsalate?
MediHelp rates the interaction as moderate. Eplerenone and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate may reduce the blood pressure lowering effect of eplerenone and may impair renal function. In patients with reduced kidney function it can add to the risk of hyperkalemia.
How serious is the interaction between Eplerenone and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, especially in older patients or those with CKD. Use the lowest effective salsalate dose for the shortest time.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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