Drug interactions
Eplerenone + Saquinavir
Severity: Contraindicated
Eplerenone and Saquinavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, given with ritonavir, strongly inhibits CYP3A4 and increases eplerenone concentrations. This raises the risk of hyperkalemia and arrhythmia.
What this interaction means in plain words
Eplerenone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition by saquinavir and its ritonavir booster decreases eplerenone metabolism.
What to do
Avoid concurrent use and choose an alternative to either drug.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Saquinavir?
MediHelp rates the interaction as contraindicated. Eplerenone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir, given with ritonavir, strongly inhibits CYP3A4 and increases eplerenone concentrations. This raises the risk of hyperkalemia and arrhythmia.
How serious is the interaction between Eplerenone and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative to either drug.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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