Drug interactions
Eplerenone + Telmisartan-amlodipine
Severity: Major
Eplerenone and Telmisartan-amlodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan and eplerenone both reduce potassium excretion, so combining them increases the risk of significant hyperkalemia. Risk is highest in renal impairment, diabetes and older age.
What this interaction means in plain words
Eplerenone and Telmisartan-amlodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eplerenone belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade and mineralocorticoid receptor antagonism both reduce renal potassium excretion.
What to do
Check potassium and creatinine within the first week and regularly thereafter, and avoid potassium supplements. Reduce or stop eplerenone if potassium rises above the accepted range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Eplerenone with Telmisartan-amlodipine?
MediHelp rates the interaction as major. Eplerenone and Telmisartan-amlodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Telmisartan and eplerenone both reduce potassium excretion, so combining them increases the risk of significant hyperkalemia. Risk is highest in renal impairment, diabetes and older age.
How serious is the interaction between Eplerenone and Telmisartan-amlodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine within the first week and regularly thereafter, and avoid potassium supplements. Reduce or stop eplerenone if potassium rises above the accepted range.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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