Drug interactions
Epoprostenol + Etodolac
Severity: Moderate
Epoprostenol and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation, so combining it with an NSAID that also impairs platelet function and irritates the gastrointestinal mucosa may increase bleeding risk.
What this interaction means in plain words
Epoprostenol and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Etodolac belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-mediated platelet inhibition plus NSAID COX inhibition.
What to do
Monitor for bleeding and bruising and check hemoglobin if symptoms arise; avoid unnecessary NSAID use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Etodolac?
MediHelp rates the interaction as moderate. Epoprostenol and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation, so combining it with an NSAID that also impairs platelet function and irritates the gastrointestinal mucosa may increase bleeding risk.
How serious is the interaction between Epoprostenol and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising and check hemoglobin if symptoms arise; avoid unnecessary NSAID use.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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