Drug interactions
Epoprostenol + Hydrochlorothiazide-losartan
Severity: Moderate
Epoprostenol and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator, and combining it with antihypertensives such as losartan and hydrochlorothiazide can increase the risk of hypotension. Diuretic-related volume depletion may add to this effect.
What this interaction means in plain words
Epoprostenol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering.
What to do
Monitor blood pressure and volume status when starting or titrating epoprostenol, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Epoprostenol and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent vasodilator, and combining it with antihypertensives such as losartan and hydrochlorothiazide can increase the risk of hypotension. Diuretic-related volume depletion may add to this effect.
How serious is the interaction between Epoprostenol and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status when starting or titrating epoprostenol, and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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