Drug interactions
Epoprostenol + Indomethacin
Severity: Moderate
Epoprostenol and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation, and indomethacin impairs platelet function and can injure the GI mucosa, so bleeding risk may rise when they are combined.
What this interaction means in plain words
Epoprostenol and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-mediated platelet inhibition plus COX inhibition.
What to do
Monitor for signs of bleeding and hemoglobin when used together. Prefer a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Indomethacin?
MediHelp rates the interaction as moderate. Epoprostenol and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation, and indomethacin impairs platelet function and can injure the GI mucosa, so bleeding risk may rise when they are combined.
How serious is the interaction between Epoprostenol and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin when used together. Prefer a non-NSAID analgesic where possible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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