Drug interactions
Epoprostenol + Ketoprofen
Severity: Moderate
Epoprostenol and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent inhibitor of platelet aggregation, and ketoprofen also impairs platelet function and can injure the gastric mucosa. Together they increase the risk of bleeding, including gastrointestinal bleeding.
What this interaction means in plain words
Epoprostenol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects: prostacyclin-mediated inhibition of aggregation plus reversible COX-1 inhibition by the NSAID.
What to do
Monitor for signs of bleeding and check hemoglobin if combined; use the lowest effective NSAID dose for the shortest time, or choose paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Ketoprofen?
MediHelp rates the interaction as moderate. Epoprostenol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol is a potent inhibitor of platelet aggregation, and ketoprofen also impairs platelet function and can injure the gastric mucosa. Together they increase the risk of bleeding, including gastrointestinal bleeding.
How serious is the interaction between Epoprostenol and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin if combined; use the lowest effective NSAID dose for the shortest time, or choose paracetamol where possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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