Drug interactions
Epoprostenol + Sulindac
Severity: Moderate
Epoprostenol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation and sulindac, as an NSAID, impairs platelet function and can injure the gastric mucosa. Together they can raise the risk of bleeding, including gastrointestinal bleeding.
What this interaction means in plain words
Epoprostenol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epoprostenol belongs to Genitourinary; Sulindac belongs to Musculoskeletal.
Why it happens
Additive antiplatelet effects through different pathways (prostacyclin-mediated platelet inhibition plus NSAID cyclooxygenase inhibition) with NSAID mucosal injury.
What to do
Monitor for signs of bleeding and check hemoglobin if therapy is prolonged. Use the lowest effective NSAID dose for the shortest time, or choose a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Epoprostenol with Sulindac?
MediHelp rates the interaction as moderate. Epoprostenol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation and sulindac, as an NSAID, impairs platelet function and can injure the gastric mucosa. Together they can raise the risk of bleeding, including gastrointestinal bleeding.
How serious is the interaction between Epoprostenol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin if therapy is prolonged. Use the lowest effective NSAID dose for the shortest time, or choose a non-NSAID analgesic.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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