Drug interactions
Eprosartan + Etodolac
Severity: Moderate
Eprosartan and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the antihypertensive effect of eprosartan and increases the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Eprosartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins, so with angiotensin receptor blockade glomerular filtration falls and potassium handling is impaired.
What to do
Monitor blood pressure, creatinine and potassium after starting or changing therapy and maintain hydration. Avoid in dehydrated or renally impaired patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Etodolac?
MediHelp rates the interaction as moderate. Eprosartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the antihypertensive effect of eprosartan and increases the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Eprosartan and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or changing therapy and maintain hydration. Avoid in dehydrated or renally impaired patients where possible.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
