Drug interactions
Eprosartan + Hydrochlorothiazide-losartan
Severity: Major
Eprosartan and Hydrochlorothiazide-losartan: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan is another angiotensin receptor blocker, so combining it with losartan gives duplicate blockade of the angiotensin II type 1 receptor. This increases the risk of hypotension, hyperkalemia and renal dysfunction without proven benefit.
What this interaction means in plain words
Eprosartan and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Duplicate AT1 receptor blockade producing additive hypotension, reduced aldosterone effect and reduced glomerular filtration.
What to do
Avoid combining two angiotensin receptor blockers; use a single agent at an optimized dose. If the combination is unavoidable, monitor blood pressure, potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Eprosartan and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan is another angiotensin receptor blocker, so combining it with losartan gives duplicate blockade of the angiotensin II type 1 receptor. This increases the risk of hypotension, hyperkalemia and renal dysfunction without proven benefit.
How serious is the interaction between Eprosartan and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two angiotensin receptor blockers; use a single agent at an optimized dose. If the combination is unavoidable, monitor blood pressure, potassium and creatinine.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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