Drug interactions
Eprosartan + Indomethacin
Severity: Moderate
Eprosartan and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the blood pressure lowering effect of eprosartan. In volume-depleted or elderly patients the combination may cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Eprosartan and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, causing sodium retention and reduced glomerular perfusion, which compounds angiotensin receptor blockade.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the combination and ensure adequate hydration. Avoid in dehydrated or renally impaired patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan and Indomethacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Indomethacin?
MediHelp rates the interaction as moderate. Eprosartan and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the blood pressure lowering effect of eprosartan. In volume-depleted or elderly patients the combination may cause acute kidney injury and hyperkalemia.
How serious is the interaction between Eprosartan and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the combination and ensure adequate hydration. Avoid in dehydrated or renally impaired patients where possible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
