Drug interactions
Eprosartan + Nebivolol
Severity: Moderate
Eprosartan and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and the combination is commonly used for this purpose, but additive hypotension can occur, especially at initiation or in volume-depleted patients. Eprosartan can raise potassium, and beta-blockers may modestly add to this.
What this interaction means in plain words
Eprosartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects; angiotensin receptor blockade reduces aldosterone-mediated potassium excretion, with a minor beta-blocker contribution.
What to do
Monitor blood pressure and serum potassium and creatinine after starting or adjusting either drug. Adjust doses if hypotension or hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Nebivolol?
MediHelp rates the interaction as moderate. Eprosartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and the combination is commonly used for this purpose, but additive hypotension can occur, especially at initiation or in volume-depleted patients. Eprosartan can raise potassium, and beta-blockers may modestly add to this.
How serious is the interaction between Eprosartan and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium and creatinine after starting or adjusting either drug. Adjust doses if hypotension or hyperkalemia occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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