Drug interactions
Eprosartan + Sulindac
Severity: Moderate
Eprosartan and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can blunt the blood pressure lowering effect of eprosartan and raises the risk of renal function deterioration, particularly in older or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Eprosartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and promotes sodium retention while the ARB dilates the efferent arteriole.
What to do
Monitor creatinine, potassium and blood pressure after initiation and periodically, and keep patients hydrated. Avoid the combination in volume-depleted or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Eprosartan with Sulindac?
MediHelp rates the interaction as moderate. Eprosartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can blunt the blood pressure lowering effect of eprosartan and raises the risk of renal function deterioration, particularly in older or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Eprosartan and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium and blood pressure after initiation and periodically, and keep patients hydrated. Avoid the combination in volume-depleted or renally impaired patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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