Drug interactions
Eprosartan + Tolfenamic acid
Severity: Moderate
Eprosartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid reduce renal prostaglandin synthesis, which can impair renal function and cause potassium retention, and they blunt the antihypertensive effect of ARBs. The combination raises the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Eprosartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID-mediated inhibition of prostaglandin-dependent renal perfusion and renin release combined with angiotensin receptor blockade.
What to do
Ensure adequate hydration and monitor blood pressure, creatinine and potassium after starting the NSAID. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Eprosartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Eprosartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid reduce renal prostaglandin synthesis, which can impair renal function and cause potassium retention, and they blunt the antihypertensive effect of ARBs. The combination raises the risk of acute kidney injury and hyperkalemia, especially in elderly or volume-depleted patients.
How serious is the interaction between Eprosartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, creatinine and potassium after starting the NSAID. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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