Drug interactions
Eprosartan + Voclosporin
Severity: Major
Eprosartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that causes nephrotoxicity and hyperkalemia, and eprosartan can reduce glomerular filtration and potassium excretion. The combination raises the risk of renal function decline and high potassium.
What this interaction means in plain words
Eprosartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent vasoconstriction and reduced potassium secretion combine with ARB-induced efferent dilation and reduced aldosterone effect.
What to do
Monitor eGFR, serum potassium and blood pressure regularly, especially at initiation and dose changes. Reduce or interrupt voclosporin according to labeling if renal function falls or potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Eprosartan with Voclosporin?
MediHelp rates the interaction as major. Eprosartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that causes nephrotoxicity and hyperkalemia, and eprosartan can reduce glomerular filtration and potassium excretion. The combination raises the risk of renal function decline and high potassium.
How serious is the interaction between Eprosartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR, serum potassium and blood pressure regularly, especially at initiation and dose changes. Reduce or interrupt voclosporin according to labeling if renal function falls or potassium rises.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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