Drug interactions
Eprosartan-hydrochlorothiazide + Etodolac
Severity: Moderate
Eprosartan-hydrochlorothiazide and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide. Together with a diuretic and angiotensin receptor blocker, NSAIDs raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and lowers renal perfusion, opposing antihypertensive effects and impairing glomerular autoregulation.
What to do
Use the lowest effective dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Etodolac?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide. Together with a diuretic and angiotensin receptor blocker, NSAIDs raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest time and ensure hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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