Drug interactions
Eprosartan-hydrochlorothiazide + Glimepiride
Severity: Minor
Eprosartan-hydrochlorothiazide and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and impair glycemic control, which may reduce the effectiveness of sulfonylureas such as glimepiride. The effect is usually modest at the low hydrochlorothiazide doses used in fixed combinations, but it can become relevant in patients with marginal control.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Glimepiride belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose the glucose-lowering action of the sulfonylurea (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c after starting or changing the combination. Adjust the antidiabetic dose if control worsens and correct potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Glimepiride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Glimepiride
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Glimepiride?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and impair glycemic control, which may reduce the effectiveness of sulfonylureas such as glimepiride. The effect is usually modest at the low hydrochlorothiazide doses used in fixed combinations, but it can become relevant in patients with marginal control.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the combination. Adjust the antidiabetic dose if control worsens and correct potassium.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
