Drug interactions
Eprosartan-hydrochlorothiazide + Indomethacin
Severity: Major
Eprosartan-hydrochlorothiazide and Indomethacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can weaken the blood pressure control of the ARB and thiazide combination. The three-way combination of NSAID, diuretic and ARB is associated with acute kidney injury and may raise potassium, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition causes sodium retention and reduces afferent arteriolar dilation, which together with angiotensin receptor blockade and diuresis impairs glomerular filtration and potassium excretion.
What to do
Avoid if possible; if needed use the shortest course at the lowest dose with monitoring of blood pressure, creatinine and potassium within the first week. Ensure adequate hydration and consider an alternative analgesic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Indomethacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Indomethacin?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can weaken the blood pressure control of the ARB and thiazide combination. The three-way combination of NSAID, diuretic and ARB is associated with acute kidney injury and may raise potassium, particularly in elderly or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed use the shortest course at the lowest dose with monitoring of blood pressure, creatinine and potassium within the first week. Ensure adequate hydration and consider an alternative analgesic.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
