Drug interactions
Eprosartan-hydrochlorothiazide + Irbesartan
Severity: Major
Eprosartan-hydrochlorothiazide and Irbesartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding irbesartan to an eprosartan-containing product results in dual ARB therapy, which gives no added benefit. It increases the risk of hypotension, hyperkalemia and renal dysfunction.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II receptor blockade causes additive reductions in aldosterone effect and glomerular filtration pressure.
What to do
Avoid using two ARBs together; use a single ARB at an optimized dose. If both have been given, monitor potassium, creatinine and blood pressure and stop one agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Irbesartan?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding irbesartan to an eprosartan-containing product results in dual ARB therapy, which gives no added benefit. It increases the risk of hypotension, hyperkalemia and renal dysfunction.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Irbesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together; use a single ARB at an optimized dose. If both have been given, monitor potassium, creatinine and blood pressure and stop one agent.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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