Drug interactions
Eprosartan-hydrochlorothiazide + Isoproterenol
Severity: Moderate
Eprosartan-hydrochlorothiazide and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol and hydrochlorothiazide may both lower serum potassium, so combined use can produce hypokalemia that raises the risk of arrhythmias. The risk is greater with high-dose or prolonged isoproterenol infusion.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-adrenergic stimulation shifts potassium into cells while thiazides increase renal potassium excretion, giving additive hypokalemia.
What to do
Monitor serum potassium and ECG during isoproterenol therapy and replace potassium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Isoproterenol?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol and hydrochlorothiazide may both lower serum potassium, so combined use can produce hypokalemia that raises the risk of arrhythmias. The risk is greater with high-dose or prolonged isoproterenol infusion.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during isoproterenol therapy and replace potassium as required.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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